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High ROS levels generated via endogenous (mitochondria, endoplasmic reticulum [ER], and NOXs) and exogenous sources (radiation, drugs, foods, cigarette smoking, and pollution) induce oxidative stress that is harmful to the host 46,47

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[DOI] [PubMed] [Google Scholar] [90].Yamaguchi T, Pelling JC, Ramaswamy NT, Eppler JW, Wallace DP, Nagao S, Rome LA, Sullivan LP, Grantham JJ, cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway11See Editorial by Grande, p